Monday, October 8, 2012

Bear Grylls making competition series for NBC

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Tuesday, October 2, 2012

charles' Site - presbyopia creon: coridiaharris9: underway binned ...

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  • Writing
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Spy App Can Turn Smartphones Against You

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CNN News: Spa Getaways - Carry On | Travel + Leisure

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Source: http://www.travelandleisure.com/travel-blog/carry-on/2012/10/1/cnn-news-spa-getaways

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Monday, October 1, 2012

gratefulness innovator: Self Improvement Month: Get Organized ...

Self Improvement WordleThis month is Self Improvement Month. All this month I will do a weekly post to help you improve yourself by getting organized.

Last week we took a home assessment for Self Improvement Month. This week we put that plan into action. This week it is time to get organized!

Look over your home assessment list and let?s get started.

  • You want to first gather your supplies. (Trash bags, boxes, sharpies, etc.)
  • You want to get started in one area first.
  • Sweep through the house organizing according to the plan you wrote out last week.
  • Immediately take out the trash and take the donations to where you have already designated them to go.
  • Start containerizing what you have decided to keep.
  • Put everything in their place. You should already have the designated spots preplanned from your outline last week.

That?s it! You now have completely organized your home. Give yourself a pat on the back and a cup of tea. Now this process can take you several weeks to complete. It?s not like the TV shows you see where everything is tip top in 48 hours. So don?t get discouraged at the length of time it may take to get everything in order. Just keep working your plan and you should have no problem having an organized home in no time.

Next week I will show you how to maintain what you have now put in order. Because maintenance is the key to success.

Until next week?

Related Posts Plugin for WordPress, Blogger...Series Navigation<< Self Improvement Month: Home Assessment

?

Samantha Pointer is the owner of Get It Together! Organizing and Pointer's Vine Web Design. She is a Blissfully Domestic Writer and the Director of Technology for NAPO Nashville. She also manages several websites and blogs. She is the mother to two beautiful girls and enjoys spending time with family and friends. Samantha is a tech geek, foodie, history buff and sports fanatic just to name a few of the hobbies she enjoys. You can find her on her computer late at night sending out emails. She loves cooking,architecture, old homes and decorating. If she was not doing what she is doing now she would have been an economist or historian.

Source: http://organizingguru.com/2012/09/self-improvement-month-get-organized/

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Source: http://gratefulness-innovator.blogspot.com/2012/09/self-improvement-month-get-organized.html

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Source: http://mcdaniel83.typepad.com/blog/2012/09/gratefulness-innovator-self-improvement-month-get-organized.html

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Source: http://eguvymyku.posterous.com/gratefulness-innovator-self-improvement-month

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Source: http://flixjamesie.blogspot.com/2012/09/gratefulness-innovator-self-improvement.html

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Source: http://hahnsean683.typepad.com/blog/2012/09/gratefulness-innovator-self-improvement-month-get-organized.html

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How immune cells defend themselves against HIV

ScienceDaily (Sep. 26, 2012) ? A team of scientists led by virologists Prof. Oliver T. Fackler and Prof. Oliver T. Keppler from Heidelberg University Hospital have decoded a mechanism used by the human immune system to protect itself from HIV viruses. A protein stops the replication of the virus in resting immune cells, referred to as T helper cells, by preventing the transcription of the viral genome into one that can be read by the cell. The ground-breaking results provide new insights into the molecular background of the immunodeficiency syndrome AIDS and could open up starting points for new treatments.

The study has now been published -- ahead of print online -- in the international journal Nature Medicine.

Human immunodeficiency viruses attack different cells of the human immune system, most frequently, "T helper cells." These lymphocytes play a key role in immune defense, since they activate other immune cells upon contact with pathogens and set off subsequent immune responses. In the course of the HIV infection, they are continuously depleted until the immune system ultimately fails, culminating in AIDS with various infections.

In healthy people, the vast majority of T helper cells in the blood are in a resting state. They are not activated until they contact the pathogens against which they are specialized in defending. In the activated state, the cells are susceptible to HIV infection. "In contrast, resting T helper cells are immune to HIV: While the virus docks, and delivers its genetic information to the cell, the infection does not progress further. We have investigated why this is the case," explained Prof. Fackler, head of the working group at the Department of Infectious Diseases, Virology. Even if the T helper cells are activated later on, the virus does not replicate, because the genetic information of the virus is degraded during this period.

HIV genome cannot be transcribed into cell-compatible version

The team is headed by Prof. Fackler and Prof. Keppler, who moved from Heidelberg to the University Hospital in Frankfurt in April 2012 and now heads the Institute of Medical Virology there. The researchers discovered that the cellular protein SAMHD1 significantly contributes to protecting the resting immune cells. The protein is present in both resting and activated T helper cells and depletes nucleotides, the building blocks of genetic information. In the active phase the cells double their genetic information and divide, a process that depends on the continoues production of nucleotides. In the resting state, the cell does not require any nucleotides and stops their production, and SAMHD1 degrades the remaining nucleotides. "As a result, the HIV viruses most likely also lack the material they need to transcribe their genetic information into a version that can be used for the cell and to allow it to replicate," Fackler explained.

In the experiment, if SAMHD1 expression was silenced, resting T helper cells became susceptible to HIV infection. The same was true for immune cells of a patient who is unable to produce SAMHD1 due to a hereditary condition. "This shows that HIV can only replicate in lymphocytes if the effect of the protective protein SAMHD1 is eliminated," Keppler said. In addition, the researchers discovered that this early protective measure must be followed by other barriers to HIV replication. Even without SAMHD1, no new viruses were released from resting T helper cells. Now that they have described the protective function of SAMHD1 and are able block it, the scientists can for the first time also investigate the downstream mechanisms. "We hope that we will be able to use these findings to develop new strategies in the fight against HIV," the virologist said.

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Story Source:

The above story is reprinted from materials provided by Heidelberg University Hospital.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Hanna-Mari Baldauf, Xiaoyu Pan, Elina Erikson, Sarah Schmidt, Waaqo Daddacha, Manja Burggraf, Kristina Schenkova, Ina Ambiel, Guido Wabnitz, Thomas Gramberg, Sylvia Panitz, Egbert Flory, Nathaniel R Landau, Serkan Sertel, Frank Rutsch, Felix Lasitschka, Baek Kim, Renate K?nig, Oliver T Fackler, Oliver T Keppler. SAMHD1 restricts HIV-1 infection in resting CD4 T cells. Nature Medicine, 2012; DOI: 10.1038/nm.2964

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/-9yz-ZgvbM4/121001095905.htm

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Dislodged seats force emergency landing at JFK

20 hrs.

NEW YORK --?American Airlines says a Boston to Miami flight had to make an emergency landing at JFK airport over the weekend due to a row of dislodged seats.

Flight 685 landed safety at Kennedy Airport on Saturday.

The unit of AMR Corp. said in a statement that passengers in the affected row were moved to three other seats.

Passengers aboard the flight were placed on another aircraft for the trip to Miami.

The airline said it was conducting an internal investigation to determine why the row of seats became loose.

It said the FAA was notified of the problem and the airline's internal review.?

Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.nbcnews.com/travel/dislodged-seats-force-emergency-landing-jfk-6206722

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